Table 3. Unadjusted t-test of significantly modulated genes between ITV+ (n = 4) and ITV- (n = 4).
| Gene Groups | Gene Name | Ratio* | P-value |
| Circadian Rhythm-Related | Neuronal PAS domain 2 (NPAS2) | 3.96 D | 0.00028 |
| Period homolog 2 (Per2) | 1.73 U | 0.00852 | |
| Aryl hydrocarbon receptor nuclear translocator-like (ARNTL) | 2.10 D | 0.00071 | |
| Adrenergic receptor, alpha 2c | 2.12 D | 0.03321 | |
| Cartilage ECM-Related | Type II collagen alpha 1 | 4.88 D | 0.02847 |
| Type IX collagen alpha 1 | n.d.** | -- | |
| Type IX collagen alpha 2 | 2.00 D | 0.02495 | |
| Type IX collagen alpha 3 | 4.65 D | 0.01270 | |
| Type X collagen alpha 1 | 12.47 D | 0.01994 | |
| Type XI collagen alpha 1 | 2.04 D | 0.04079 | |
| Hyaluronan and proteoglycan link protein 1 (Hapln1) | 3.43 D | 0.03612 | |
| Dermatan sulfate proteoglycan 3 | 3.15 D | 0.00980 | |
| Aggrecan | 2.07 D | 0.01696 | |
| Sox9 | n.d. | -- | |
| Catenin | n.d. | -- | |
| Bone ECM-Related | Type I collagen alpha 1 | n.d. | -- |
| Type I collagen alpha 2 | n.d. | -- | |
| Type V collagen alpha 1 | n.d. | -- | |
| Type V collagen alpha 2 | n.d. | -- | |
| Type V collagen alpha 3 | n.d. | -- | |
| SPP1 (Osteopontin) | n.d. | -- | |
| Osteocalcin | n.d. | -- | |
| SPARC (Osteonectin) | n.d. | -- | |
| Matrix Gla Protein | n.d. | -- | |
| Alkaline phosphatase | n.d. | -- | |
| Runx2 | n.d. | -- | |
| Hypoxia-Related | Hypoxia-inducible factor 1 alpha | n.d. | -- |
| Heat shock protein 1 | 1.61 D | 0.03421 |
*Average gene expression ratio from microarray data analyzed by GeneSifter. D = down-regulated in ITV-; U = up-regulated in ITV-.
**n.d. = not detected within the threshold of 1.5-fold change.