Figure 2.

Novel domain combinations in P. infestans ePKs. Indicated are six proteins that contain accessory domains not described previously for ePKs, drawn approximately to scale. The novel domains are RhoGAP, a domain found on GTPase activating proteins; the WW protein interaction domain, which was found on a dual-kinase protein; the Arb2 domain which associates with chromatin and may influence histone methylation and siRNA formation; the N and C-terminal alpha fold domains of cyclins, cyc_N and cyc_C, which may be cell cycle control or protein interaction domains; the RyR ryanodine receptor domain, which are found on some Ca²⁺ channels and other proteins but have unknown functions; and the PAS signal sensor domain. The latter is located just upstream of PAC, which is a structural domain that is believed to contribute to the activity of the PAS fold. PITG_12903 also contains a predicted phosphatidylinositol-binding PH (Pleckstrin Homology) domain, which is commonly found on ePKs, as is the zinc and phosphatidylinositol 3-phosphate-binding FYVE domain shown on PITG_01365.