Table 2.
Non-kinase domains in ePKs from P. infestans
| Pfam Domain | No. of Proteinsa | Represented Families | Function | Novel?b |
|---|---|---|---|---|
| Ankyrin | 3 | AGC, TKL | higher order structure | |
| Arb2 | 2 | AGC | chromatin association | ✓ |
| Armadillo | 1 | TKL | protein interaction | |
| C2 | 1 | AGC | Ca2+-dependent membrane targeting | |
| cNMP binding | 8 | AGC, CAMK | cyclic nucleotide binding | |
| cyclin N, C | 4 | CMGC | cell cycle control | ✓ |
| DEP | 5 | AGC, TKL | protein targeting and interaction | |
| EF hand | 3 | CAMK, OTHER | calcium binding | |
| FYVE | 2 | AGC | zinc binding | |
| HEAT | 1 | OTHER | protein interaction | |
| KA1 | 4 | CAMK | kinase associated, unknown | |
| LRR | 16 | TKL | protein interaction | |
| NAF | 2 | CAMK | unknown | |
| PAS | 1 | CMGC | signal sensor | ✓ |
| PDZ | 1 | TKL | protein interaction | |
| PH | 9 | AGC, CAMK, CMGC | phosphatidylinositol binding | |
| PhoD | 1 | STE | phosphatase | |
| PP2C | 4 | AGC, CAMK, OTHER | protein phosphatase | |
| PX | 3 | AGC | phosphoinositide binding | |
| Response Reg | 1 | OTHER | two-component signaling | |
| RhoGAP | 1 | STE | GTPase activating protein | ✓ |
| RWD | 2 | OTHER | unknown | |
| RyR | 1 | CAMK | unknown | ✓ |
| SAM | 2 | STE, TKL | protein interaction | |
| SET | 1 | CMGC | protein interaction | |
| TPR | 1 | TKL | protein interaction | |
| UBA/TS-N | 1 | CAMK | ubiquitin binding | |
| WD40 | 1 | OTHER | protein interaction | |
| WW | 1 | CMGC | protein interaction | ✓ |
| ZF-B | 1 | STE | zinc binding |
a If a protein contains more than one given domain it is counted only once in that category.
b Indicates combination of kinase domain and accessory domain not reported previously outside of Phytophthora.