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. Author manuscript; available in PMC: 2012 Jun 1.
Published in final edited form as: Neuropharmacology. 2010 Sep 22;60(7-8):1058–1063. doi: 10.1016/j.neuropharm.2010.09.006

Figure 1.

Figure 1

Effect of a 4-day treatment with cocaine and minocycline on the locomotor activity of 5-LOX (−/−) mice. Minocycline (M; 40 mg/kg) or vehicle (Veh) were administrated daily 3 h before i.p. injection of cocaine (C; 10 mg/kg) or its vehicle (n = 6). Locomotor activity was measured for 30 min starting immediately after the last daily i.p. injection. Repeated ANOVA revealed that significant difference occurred among Veh and C or M+C groups [day, F (1, 15) = 4.61, p<0.05; group, F (3, 15) = 14.57, p<0.05; day × group, F (3, 15) = 3.68, p<0.05], but not between C and M+C groups (* p<0.05 vs the corresponding control groups, i.e., Veh and M, respectively; t-test).