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. Author manuscript; available in PMC: 2012 Jun 1.
Published in final edited form as: Neuropharmacology. 2010 Sep 22;60(7-8):1058–1063. doi: 10.1016/j.neuropharm.2010.09.006

Figure 2.

Figure 2

Effect of a 4-day treatment with cocaine and minocycline on GluR1 phosphorylation in 5-LOX (−/−) mice. The 4-day treatment was conducted as described in Fig. 1 (Veh = vehicle, C = cocaine, M = minocycline). Samples were collected 30 min after the last injection. The phosphorylation status of GluR1 at Ser831 and Ser845 sites was assayed by quantitative Western blot in the frontal cortex (A, C) and the striatum (B, D). The optical density of the phospho Ser831 and phospho Ser845 bands was corrected by the density of the corresponding total GluR1 bands (examples shown in C and D). The results are expressed as a percentage of the corresponding vehicle-treated controls (mean ± S.E.M.; n = 6). There were no significant differences between groups (one-way ANOVA).