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Dose-effect of 17β-estradiol (E2) replacement on plasma creatinine (A) and creatinine clearance (CrCl) (B) in ovariectomized (ovx) mice. s-ovx: sham ovariectomy; pl: placebo; 0.02 μg/day: E2-low dose; 0.42 μg/day: E2-moderate dose; 4.2 μg/day: E2-high dose.
