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. Author manuscript; available in PMC: 2012 Jan 17.
Published in final edited form as: Life Sci. 2010 Nov 11;88(3-4):178–186. doi: 10.1016/j.lfs.2010.11.008

Figure 6.

Figure 6

Dose-effect of 17β-estradiol (E2) replacement on tubulointerstitial injury score. Left panels: representative images ofhigh -dose E2-induced tubulointerstitialinjury; A: dilated tubules combined with flattened epithelial cells, loss of the brush border, dead cells and/or cell fragments and casts in the lumen as well as increased distance between two neighboring tubules; B: interstitial fibrosis (picrosirius red staining); and C: renal calcium deposition (von Kassa staining, showing dark calcium crystals using a dark filed and polarized light). s-ovx: sham ovariectomy; pl: placebo; 0.02 μg/day: E2-low dose; 0.42 μg/day: E2-moderate dose; 4.2 μg/day: E2-high dose.