Table 2.
Dose-Effect of Estrogen on Left Ventricular Function, Morphologyand Histolog y.
| Groups |
Sham-ovx | ovx + placebo | ovx +E2 |
||
|---|---|---|---|---|---|
| Parameters | ovx + L | ovx + M | ovx + H | ||
| SBP (mmHg) | 105±5 | 104±2 | 106±4 | 106±3 | 101±3 |
| HR (beats/min) | 659±19 | 649±14 | 659±10 | 658±13 | 629±15 |
| dP/dtmax/iP (sec−1) | 98±3 | 91±7 | 107±13 | 122±7 | 94±1 |
| dP/dtmin (mmHg/sec) | −3022±107 | −2837±270 | −3293±431 | −3539±347 | −2957±245 |
| LVDs (mm) | 1.06±0.06 | 1.11±0.03 | 1.08±0.02 | 1.16±0.04 | 1.18±0.04* |
| LVDd (mm) | 2.07±0.09 | 2.23±0.06 | 2.19±0.04 | 2.35±0.04* | 2.27±0.06* |
| PWTd (mm) | 0.77±0.02 | 0.80±0.02 | 0.78±0.01 | 0.84±0.02 | 0.87±0.01*§ |
| LVAs (mm2) | 0.71±0.10 | 0.75±0.01 | 0.79±0.02 | 0.88±0.04*† | 1.0±0.09*†§ |
| LVAd(mm2) | 3.62±0.03 | 3.95±0.16 | 4.07±0.13 | 4.35±0.18* | 4.41±0.2*† |
| LV mass (mg/10 g) | 21.2±4.1 | 22.7±0.5 | 20.9±0.8 | 27.4±1.5*†§ | 27.5±1.4*†§ |
| EF (%) | 80.5±1.3 | 80.9±0.5 | 80.7±0.5 | 79.7±0.7 | 77.5±1.1 |
| ICF (%) | 4.7±0.3 | 5.9±0.4* | 4.7±0.4† | 5.7±0.5* | 6.1±0.2*§ |
| MCSA (mm2) | 141±3 | 151±2* | 142±3† | 150±2* | 148±5*§ |
ovx: ovariectomy; E2: 17β-estradiol; L: low dose (0.02 μg/day); M: moderate dose (0.42 μg/d); H: high dose (4.2 μg/d). SBP: systolic blood pressure; HR: heart rate; iP: left ventricular instant pressure; LVDs and LVDd: LV systolicand diastolic dimensions; PWTd: diastolic posterior wall thickness; LVAsand LVAd: LV systolic and diastolic area; EF: ejection fraction; ICF: interstitial collagen fraction; MCSA: myocyte cross-sectional area.
*
p < 0.05 vssham -ovx;
†
p < 0.05 vs ovx +placebo;
§
p < 0.05 vs ovx +L.