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. Author manuscript; available in PMC: 2012 Jan 1.
Published in final edited form as: Exp Neurol. 2010 Oct 20;227(1):128–135. doi: 10.1016/j.expneurol.2010.10.003

Figure 1. Pioglitazone treatment attenuates mitochondrial dysfunction after TBI.

Figure 1

In order to assess the ability of Pioglitazone to prevent the mitochondrial dysfunction which occurs with this model of TBI, mitochondrial bioenergetic function was analyzed 1 day following a controlled cortical impact TBI. A. Following a single injection of Pioglitazone (10mg/kg) 15 minutes after the injury, no improvements in mitochondrial function were observed. B. When Pioglitazone was administered at both at 15 minutes and 24 hours after the injury (10mg/kg/injection) a significant increase in mitochondrial bioenergetics was observed. These studies indicate that treatment with Pioglitazone at 15 minutes and 24 hours is capable of preventing mitochondrial dysfunction following TBI.

(* p<0.01 by one-way ANOVA with SNK post-test).