Skip to main content
. Author manuscript; available in PMC: 2012 Jan 1.
Published in final edited form as: J Mol Cell Cardiol. 2010 Nov 6;50(1):128–136. doi: 10.1016/j.yjmcc.2010.11.001

Fig. 6.

Fig. 6

Involvement of late INa in Ang II-induced EADs. (A). The specific INa blocker TTX (10 µM) further shortened APD after EADs were eliminated by nifedipine. (B). The selective inhibitor of late INa, ranolazine (Ran), also abolished EADs induced by Ang II. (C). Representative INa traces under control condition (Ctl), in the presence of Ang II, and Ang II + KN-93. (D). A bar graph summarizing 1 µM Ang II-induced increase of late INa, which is significantly suppressed by 1mM trolox, 1 µM apocynin, or 1 µM KN-93, respectively.