Figure 3. Lipoxin Receptor signaling dampens neutrophil accumulation in cardiac allograft rejection.
Heterotopic cardiac transplants were performed (see Methods). When a transplanted heart pulse was no longer palpable, allografts were removed. (a) Representative heart tissue sections (magnification: ×200) were obtained from formalin-fixed, paraffin-embedded tissue, prepared and stained for CD45 (top row) or esterase (bottom row). (b) Tissue morphometric analyses were performed to determine the impact of ALX-tg expression on PMN accumulation in cardiac tissues. Values reported are the mean ± S.E. for more than 3 independent experiments with n ≥ 3 mice in each group. *P < 0.05 (ALX-tg host vs. donated organ)