Table 1.
ALX-tg recipients have increased cardiac allograft survival
Donor Strain | Recipient Strain | Lipoxin A4 Analog | Allograft Survival (d) | Mean +/− SE |
---|---|---|---|---|
FVB | BALB/c | − | 8,8,9,9,9 | 8.6 +/− 0.3 |
FVB ALX-tg | BALB/c | − | 9,9 | 9.0 |
FVB ALX-tg | BALB/c | + | 8,9,10 | 9.0 +/− 0.6 |
BALB/c | FVB | − | 7,9,9,10,10 | 9.0 +/− 0.6 |
BALB/c | FVB ALX-tg | − | 10,10,11,11,11 | 10.6 +/− 0.3* |
BALB/c | FVB ALX-tg | + | 11,12,12 | 11.7 +/− 0.3*,† |
Heterotopic cardiac transplants were performed as described in Materials and Methods. Allograft survival was assessed as the number of days that a pulse could be palpated in the allograft. Mean survival time in days of allografts in each experimental group.
P<0.05 for FVB ALX-tg compared to FVB organ recipient and
P<0.05 for comparison between ALX-tg with and without LXA4 analog (ATLa).