Skip to main content
. Author manuscript; available in PMC: 2012 Jan 25.
Published in final edited form as: Brain Res. 2010 Nov 6;1370:80–88. doi: 10.1016/j.brainres.2010.11.006

Figure 2.

Figure 2

Figure 2

Figure 2

Effects of GDNF on phenotypic markers of DA terminals in striatum. Significant loss of TH (panel A), DAT (panel B), and VMAT2 (panel C), was observed in the striatum after 6-OHDA (* p < 0.01 vs. vehicle and GDNF). Animals given 6-OHDA with GDNF displayed significant loss of these markers after 2 wks when compared to animals that just received vehicle or GDNF (* p < 0.01). However, this 6-OHDA-induced loss was greatly attenuated by GDNF at 4 and 8 wks (†p < 0.01; ††p < 0.001 vs. 6-OHDA alone) and was not statistically different from animals treated with just vehicle or GDNF. All values are expressed as average lesion area in mm2 ± SEM.

HHS Vulnerability Disclosure