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Effects of GDNF on DA content in the striatum after 6-OHDA. 6-OHDA-treated animals displayed a significant decrease in DA content (* p < 0.01). An injection of GDNF 6 hr prior to 6-OHDA infusion into the same location prevented this loss of DA content as assessed 2 and 4 wks later. Vehicle and GDNF animals showed no significant loss of DA content in the striatum. All values are expressed as a percent of loss of DA content compared to the contralateral side ± SEM.
