Table 3.
Effects of the aqueous extract of C. sativus on the tail withdrawal reflex of mice induced by the tail immersion method
| Groups | Dose (mg/kg) | Mean reaction time before and after treatment |
% inhibition |
|||||
|---|---|---|---|---|---|---|---|---|
| 0 minutes | 30 minutes | 60 minutes | 90 minutes | 30 minutes | 60 minutes | 90 min | ||
| Group I | - | 2.64 ± 0.19 | 2.94 ± 1.72 | 2.87 ± 0.44 | 2.93 ± 1.35 | - | - | - |
| Group II | 250 | 1.96 ± 1.73 | 3.88 ± 0.97* | 5.78 ± 0.43* | 5.18 ± 0.62 | 24.23 | 50.35 | 43.44 |
| Group III | 500 | 2.27 ± 2.14 | 5.57 ± 0.58** | 5.57 ± 0.58** | 6.69 ± 0.14** | 47.22 | 58.59 | 56.2 |
| Group IV | 50 | 2.43 ± 0.76 | 7.62 ± 2.43* | 10.51 ± 1.13* | 10.74 ± 2.57* | 61.42 | 72.69 | 72.72 |
Group I animals received vehicle (1% Tween 80 in distilled water), Groups II and III received 250 and 500 mg/kg body weight (orally) of the crude extract of C. sativus, and Group IV were treated with 50 mg/kg Diclofenac sodium (i.p.). Values are mean ± SEM, (n = 6);
*
P < 0.05
**
P < 0.001 Student’s t- test was applied to compare with the control