Table 2.

Percentage blood glucose reduction with glibenclamide in healthy albino rats before and after esomeprazole

	Esomeprazole (1.8 mg/kg) + glibenclamide (40 µg /kg)		Esomeprazole (3.6 mg/kg) + glibenclamide (40 µg /kg)		Esomeprazole (30 mg/kg) + glibenclamide (40 µg /kg)
	Before esomeprazole (mean±SEM)	After esomeprazole (mean±SEM)	Before esomeprazole (mean±SEM)	After esomeprazole (mean±SEM)	Before esomeprazole (mean±SEM)	After esomeprazole (mean±SEM)
Fasting	-	-	-	-	-	-
0.5	28.96±3.78	13.58 ± 2.35**	21.75±2.53	17.36± 5.41	16.36±1.72	42.91±1.04***
1.0	44.91±4.02	23.35 ± 2.19***	29.11 ± 3.90	25.71±4.87	38.80±8.81	64.16±0.85**
2.0	52.05±5.59	31.26 ± 2.66**	42.71 ± 3.30	36.16±2.80	42.43±9.72	70.52±0.52**
4.0	60.49±3.65	43.39 ± 1.39***	55.20 ± 1.97	47.56±3.55*	57.51±3.00	–
6.0	70.17±2.09	53.32 ± 2.01***	60.11 ± 1.09	52.69±1.76**	64.97±1.42	72.05±4.93
8.0	58.07±3.55	66.72 ± 1.06*	69.14±2.40	58.49±4.41*	58.66±3.21	65.79±1.84*
12.0	40.77±4.72	57.80 ± 3.57**	68.29 ± 3.80	67.25±2.51	58.38±3.93	56.60±3.86
18.0	33.85±4.02	44.39±3.45*	52.06±2.94	60.60±4.59	50.92±2.79	51.86±1.40
24.0	27.98±5.90	33.61±3.62	44.64±4.59	49.29±5.16	45.68±1.16	–
30.0	25.07±5.95	29.77±3.03	35.18±2.99	38.62±5.40	45.05±2.78	68.68±1.44***
36.0	31.33±9.53	21.73±3.05	29.84±4.92	29.97±3.73	38.35±3.65	58.63±2.91***
42.0	20.93±4.57	16.68±2.58	16.87±3.73	20.70±2.46	37.04±1.28	55.02±1.75***
48.0	13.62±3.39	8.54±3.20	11.06±2.35	8.49±2.19	32.34±2.56	46.74±1.20***

^*Significant at P<0.05;

^**Highly significant at P<0.01;

^***Very highly significant at P<0.001