Figure 3.
Inhibition of orthotopic tumor formation by anti-PSCA mAb. LAPC-9 (5 × 105) cells were injected into each dorsal lobe of the prostate in male SCID mice. After 2 days, mice (n = 6) were injected i.p. with 200 μg of 1G8 (■) or PBS (⧫) three times per week for 2 weeks. (A) Tumor growth was monitored by measuring PSA levels on the indicated days. Each data point represents the mean serum PSA levels (± SEM) for each group of six mice. (B) Significant prolongation of survival of mice treated with 1G8 (■) compared with mice treated with PBS (⧫). The percentage of survival is shown for each group at the indicated time points.