Influence of NS 1619 (10−8 and 10−6 M) on pial artery diameter in newborn male (A) and female (B) piglets before injury (Control; sham control), 1 h after FPI (FPI), 1 h after FPI treated 30 min prior to injury with phenylephrine (FPI + Phe pre-treat; 1 μg/kg/min IV), 1 h after FPI treated with Phe 30 min after injury (FPI + Phe post-treat), 1 h after FPI treated with Phe + U 0126 (FPI + Phe + U 0126 pre-treat; 1 mg/kg IV) 30 min prior to injury, and 1 h after FPI treated with Phe + U 0126 30 min after injury (FPI + Phe + U 0126 post-treat; n = 5; *p < 0.05 compared with corresponding control value; +p < 0.05 compared with corresponding FPI untreated value; #p < 0.05 compared with corresponding female value; FPI, fluid percussion injury).