Table 2.
Association between RXRA and VDR genes and metachronous colorectal neoplasia.
| Any metachronous | Proximal metachronous | Distal metachronous | |||||||
|---|---|---|---|---|---|---|---|---|---|
| neoplasia | neoplasia | neoplasia | |||||||
| OR | 95%CI | OR | 95%CI | OR | 95%CI | ||||
| RXRA | |||||||||
| PC1 | 1.01 | (0.96–1.05) | 1.01 | (0.97–1.06) | 0.97 | (0.93–1.03) | |||
| PC2 | 0.90 | (0.83–0.99) | 0.88 | (0.80–0.97) | 1.01 | (0.91–1.12) | |||
| PC3 | 1.12 | (1.00–1.25) | 1.10 | (0.98–1.24) | 1.03 | (0.91–1.17) | |||
| PC41 | 1.09 | (0.94–1.28) | 1.10 | (0.94–1.30) | 1.15 | (0.96–1.38) | |||
| LRT p-value2 | 0.04 | 0.03 | 0.49 | ||||||
| VDR | |||||||||
| PC1 | 0.98 | (0.93–1.03) | 1.00 | (0.95–1.06) | 1.00 | (0.94–1.06) | |||
| PC2 | 0.97 | (0.92–1.02) | 0.96 | (0.91–1.02) | 1.00 | (0.93–1.06) | |||
| PC3 | 1.03 | (0.95–1.10) | 0.99 | (0.92–1.07) | 1.06 | (0.98–1.16) | |||
| PC4 | 0.96 | (0.88–1.04) | 0.94 | (0.86–1.03) | 0.97 | (0.98–1.16) | |||
| PC5 | 1.06 | (0.93–1.19) | 1.02 | (0.89–1.16) | 1.02 | (0.88–1.18) | |||
| PC6 | 1.13 | (0.99–1.30) | 1.14 | (0.99–1.31) | 1.01 | (0.86–1.17) | |||
| PC7 | 1.03 | (0.89–1.20) | 1.00 | (0.85–1.16) | 0.97 | (0.82–1.15) | |||
| PC81 | 1.19 | (1.02–1.40) | 1.21 | (1.02–1.43) | 0.98 | (0.81–1.17) | |||
| LRT p-value2 | 0.11 | 0.18 | 0.96 | ||||||
1
An 80% explained-variance threshold is used for including principal components (PC) in the model.
2
P-value for each model is from a likelihood ratio test (LRT) with degrees of freedom equal to the number of principal components.