Table 3.
Haplotypes on RXRA and VDR genes and association with metachronous colorectal neoplasia.
| Haplotype | Count | Any Metachronous | Proximal Neoplasia | Distal Neoplasia | |||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| N | (%) | OR | 95%CI | N | (%) | OR | 95%CI | N | (%) | OR | 95%CI | ||
| RXRA, block 11 | |||||||||||||
| GTGC | 1857 | 857 | (46.1) | 1.00 | ref | 617 | (33.5) | 1.00 | ref | 428 | (23.2) | 1.00 | ref |
| AAAC | 523 | 252 | (48.2) | 1.09 | (0.89–1.32) | 185 | (35.6) | 1.10 | (0.89–1.34) | 132 | (25.4) | 1.12 | (0.90–1.41) |
| GAGA | 319 | 126 | (39.5) | 0.76 | (0.60–0.97) | 83 | (26.1) | 0.70 | (0.54–0.92) | 82 | (25.8) | 1.15 | (0.87–1.51) |
| GAAC | 86 | 45 | (52.3) | 1.28 | (0.83–1.97) | 34 | (40.5) | 1.35 | (0.86–2.11) | 22 | (26.2) | 1.17 | (0.71–1.93) |
| GAGC | 86 | 38 | (44.2) | 0.92 | (0.60–1.43) | 26 | (30.2) | 0.86 | (0.54–1.38) | 21 | (24.4) | 1.07 | (0.64–1.77) |
| rare | 7 | 2 | (28.6) | 0.47 | (0.09–2.41) | 1 | (14.3) | 0.33 | (0.04–2.75) | 1 | (14.3) | 0.55 | (0.07–4.59) |
| p=0.1145 | p=0.0284 | p=0.8075 | |||||||||||
| RXRA, block 22 | |||||||||||||
| AGAACG | 1989 | 927 | (46.6) | 1.00 | ref | 674 | (34.2) | 1.00 | ref | 467 | (23.7) | 1.00 | ref |
| CAGGAG | 482 | 230 | (47.7) | 1.05 | (0.86–1.28) | 165 | (34.5) | 1.02 | (0.82–1.25) | 121 | (25.3) | 1.09 | (0.87–1.38) |
| CGGGCA | 383 | 150 | (39.2) | 0.74 | (0.59–0.92) | 98 | (25.7) | 0.67 | (0.52–0.86) | 91 | (23.9) | 1.01 | (0.78–1.31) |
| rare | 24 | 13 | (54.2) | 1.35 | (0.60–3.04) | 9 | (37.5) | 1.16 | (0.50–2.66) | 7 | (29.2) | 1.33 | (0.55–3.22) |
| p=0.0325 | p=0.0097 | p=0.8246 | |||||||||||
| RXRA, block 33 | |||||||||||||
| AAGGG | 1853 | 861 | (46.5) | 1.00 | ref | 622 | (33.8) | 1.00 | ref | 429 | (23.3) | 1.00 | ref |
| GCAAA | 501 | 234 | (46.7) | 1.01 | (0.83–1.23) | 169 | (34.0) | 1.01 | (0.82–1.24) | 122 | (24.5) | 1.07 | (0.85–1.35) |
| GAGGA | 249 | 112 | (45.0) | 0.94 | (0.72–1.23) | 77 | (31.2) | 0.89 | (0.67–1.18) | 66 | (26.7) | 1.20 | (0.89–1.62) |
| GAGAA | 186 | 73 | (39.2) | 0.74 | (0.55–1.01) | 49 | (26.5) | 0.70 | (0.50–0.99) | 45 | (24.3) | 1.06 | (0.74–1.50) |
| GAGGG | 35 | 18 | (51.4) | 1.22 | (0.62–2.38) | 15 | (42.9) | 1.47 | (0.75–2.88) | 7 | (20.0) | 0.82 | (0.36–1.89) |
| AAAGG | 23 | 9 | (39.1) | 0.74 | (0.32–1.72) | 4 | (17.4) | 0.41 | (0.14–1.22) | 8 | (34.8) | 1.75 | (0.74–4.16) |
| AAGGA | 12 | 4 | (33.3) | 0.58 | (0.17–1.92) | 3 | (25.0) | 0.65 | (0.18–2.42) | 3 | (25.0) | 1.09 | (0.30–4.06) |
| rare | 19 | 9 | (47.4) | 1.04 | (0.42–2.56) | 7 | (36.8) | 1.14 | (0.45–2.91) | 6 | (31.6) | 1.52 | (0.57–4.01) |
| p=0.6040 | p=0.2091 | p=0.8086 | |||||||||||
| VDR, block 14 | |||||||||||||
| GAG | 1407 | 655 | (46.6) | 1.00 | ref | 457 | (32.8) | 1.00 | ref | 332 | (23.8) | 1.00 | ref |
| GGA | 1106 | 508 | (45.9) | 0.98 | (0.83–1.14) | 376 | (34.2) | 1.07 | (0.90–1.26) | 258 | (23.5) | 0.98 | (0.82–1.18) |
| AAG | 306 | 130 | (42.5) | 0.85 | (0.66–1.09) | 101 | (33.1) | 1.02 | (0.78–1.32) | 73 | (23.9) | 1.01 | (0.75–1.35) |
| GAA | 41 | 18 | (43.9) | 0.90 | (0.48–1.68) | 7 | (17.1) | 0.42 | (0.19–0.96) | 16 | (39.0) | 2.05 | (1.08–3.88) |
| rare | 18 | 9 | (50.0) | 1.15 | (0.45–2.91) | 5 | (27.8) | 0.79 | (0.28–2.23) | 7 | (38.9) | 2.04 | (0.78–5.29) |
| p=0.7591 | p=0.1792 | p=0.1537 | |||||||||||
| VDR, block 25 | |||||||||||||
| GCCGG | 1018 | 482 | (47.3) | 1.00 | ref | 337 | (33.4) | 1.00 | ref | 253 | (25.1) | 1.00 | ref |
| GCAAG | 956 | 426 | (44.6) | 0.89 | (0.75–1.07) | 300 | (31.5) | 0.92 | (0.76–1.11) | 236 | (24.8) | 0.98 | (0.80–1.21) |
| AACAA | 381 | 169 | (44.4) | 0.89 | (0.70–1.12) | 120 | (31.7) | 0.92 | (0.72–1.19) | 93 | (24.5) | 0.97 | (0.74–1.28) |
| GACAA | 368 | 178 | (48.4) | 1.04 | (0.82–1.32) | 134 | (36.9) | 1.17 | (0.91–1.50) | 76 | (20.9) | 0.79 | (0.59–1.06) |
| GCCAA | 128 | 57 | (44.5) | 0.89 | (0.62–1.29) | 48 | (37.5) | 1.19 | (0.82–1.75) | 26 | (20.3) | 0.76 | (0.48–1.20) |
| GACAG | 18 | 6 | (33.3) | 0.56 | (0.21–1.49) | 5 | (27.8) | 0.77 | (0.27–2.17) | 1 | (5.6) | 0.18 | (0.02–1.33) |
| rare | 9 | 2 | (22.2) | 0.32 | (0.07–1.54) | 2 | (22.2) | 0.57 | (0.12–2.75) | 1 | (11.1) | 0.37 | (0.05–3.00) |
| p=0.3939 | p=0.4642 | p=0.1518 | |||||||||||
| VDR, block 36 | |||||||||||||
| AAGAA | 1011 | 477 | (47.2) | 1.00 | ref | 334 | (33.4) | 1.00 | ref | 250 | (25.0) | 1.00 | ref |
| GGGGA | 977 | 433 | (44.3) | 0.89 | (0.75–1.06) | 307 | (31.6) | 0.92 | (0.76–1.11) | 237 | (24.4) | 0.97 | (0.79–1.19) |
| AAAAG | 649 | 291 | (44.8) | 0.91 | (0.75–1.11) | 224 | (34.7) | 1.06 | (0.86–1.31) | 148 | (22.9) | 0.89 | (0.71–1.13) |
| AGGGA | 184 | 93 | (50.5) | 1.14 | (0.84–1.57) | 61 | (33.7) | 1.02 | (0.73–1.42) | 40 | (22.1) | 0.85 | (0.58–1.25) |
| rare | 57 | 26 | (45.6) | 0.94 | (0.55–1.60) | 20 | (35.1) | 1.08 | (0.62–1.89) | 11 | (19.3) | 0.72 | (0.37–1.41) |
| p=0.4719 | p=0.7460 | p=0.7207 | |||||||||||
1
RXRA, block 1 includes: rs11102986, rs11103473, rs10776909, rs12004589
2
RXRA, block 2 includes: rs1805352, rs3132297, rs3132296, rs3118529, rs3118536, rs7861779
3
RXRA, block3 includes: rs3118571, rs3118570, rs1536475, rs3132293, rs877954
4
VDR, block 1 includes: rs11574143, rs731236, rs1544410
5
VDR, block 2 includes: rs11574026, rs10875695, rs11168293, rs4760655, rs7299460
6
VDR, block 3 includes: rs4760658, rs4516035, rs11568820, rs7310552, rs7970314
7
Likelihood ratio test p-value for a model with these haplotypes vs an intercept-only model