TABLE 1.
Drug | Class | EC50 (μM) | EC95 (μM) | CC50 (μM) | SIb |
---|---|---|---|---|---|
RAL | INSTI | 0.0084 ± 0.0022 | 0.090 ± 0.004 | >100 | >11,904 |
EVG | INSTI | 0.0029 ± 0.0007 | 0.037 ± 0.004 | 34.0 | 11,724 |
AZT | NRTI | 0.077 ± 0.028 | 0.81 ± 0.09 | >100 | >1,298 |
TDF | NtRTI | 0.030 ± 0.003 | 0.50 ± 0.033 | >100 | >3,333 |
NVP | NNRTI | 0.073 ± 0.044 | 0.68 ± 0.14 | >100 | >1,369 |
EFV | NNRTI | 0.0011 ± 0.0005 | 0.008 ± 0.0004 | 35.0 | 31,818 |
Means ± standard deviations obtained from at least three independent experiments, with each experiment conducted in duplicate.
SI, selectivity index (CC50/EC50).