TABLE 3.

In vitro susceptibility of each drug according to species tested

Drug	P. malariae				P. ovale
	Majority trophozoites		Majority rings		Majority trophozoites		Majority rings
	na	Median IC50b (range)	n	Median IC50 (range)	n	IC50	n	Median IC50 (range)
Chloroquine	23	127.9 (7.9-2980)	7	14.0c (3.5-27.0)	1	23.2	3	7.8 (3.3-17.3)
Amodiaquine	20	19.1 (2.5-96.4)	9	21.7 (2.8-40.3)	0		5	4.3 (1.0-12.8)
Artesunate	17	2.84 (0.15-15.8)	7	1.77 (0.27-9.3)	1	1.28	4	1.16 (0.17-2.85)
Mefloquine	19	46.9 (9.8-336.9)	6	36.8 (4.8-164.0)	0		5	23.8 (6.2-49.9)
Pyronaridine	13	7.8 (0.1-150)	2	4.1 (0.53-7.6)	0		3	0.72 (0.17-1.39)
Piperaquine	22	38.4 (6.3-698)	8	29.0 (6.6-35.9)	1	7.57	5	10.2 (4.7-15.5)

^an, number of assays with acceptable IC₅₀ data.

^bIC₅₀s are given in nM concentrations.

^cP = 0.01, comparing IC₅₀s in isolates with majority trophozoites to those with majority rings.