TABLE 3.
Inhibitory sigmoid Emax model parameter | Result in system |
||
---|---|---|---|
Mouse | Hollow fiber | Patient sputum | |
EC50 (AUC0-24/MIC) ratio | 63 | 62 ± 28 | —a |
Hill coefficient (slope) | 1.0 | 0.9 ± 0.4 | 1.0 ± 0.4 |
Emax for EBAb (log10 CFU/ml per day) | —c | 0.9 ± 0.2 | 0.6 ± 0.1 |
r2 | 0.83 | 0.97 | 0.95 |
Reported as mg/kg/day.
EBA, early bactericidal activity.
Calculated as 0.2 log10 CFU/g of mouse lung.