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Isoniazid inhibitory sigmoid Emax curve in the hollow-fiber system, mice, and humans
| Inhibitory sigmoid Emax model parameter | Result in system |
||
|---|---|---|---|
| Mouse | Hollow fiber | Patient sputum | |
| EC50 (AUC0-24/MIC) ratio | 63 | 62 ± 28 | —a |
| Hill coefficient (slope) | 1.0 | 0.9 ± 0.4 | 1.0 ± 0.4 |
| Emax for EBAb (log10 CFU/ml per day) | —c | 0.9 ± 0.2 | 0.6 ± 0.1 |
| r2 | 0.83 | 0.97 | 0.95 |
Reported as mg/kg/day.
EBA, early bactericidal activity.
Calculated as 0.2 log10 CFU/g of mouse lung.
