TABLE 4.
Isolate | Group | Gene inactivated | MIC (μg/ml) of: |
|||||
---|---|---|---|---|---|---|---|---|
Cip | Cip + res | Cip + NaO | EtBr | EtBr + res | EtBr + NaO | |||
R6 | Control | 0.5 | 0.5 | 0.25 | 1 | 0.25 | 0.12 | |
M42 | FQDR | 64 | 32 | 16 | 8 | 0.5 | 1 | |
M298 | patA | 8 | 8 | 8 | 0.5 | 0.5 | 0.5 | |
M299 | patB | 8 | 8 | 8 | 0.5 | 0.5 | 0.5 | |
M45 | FQDR | 4 | 1 | 1 | 4 | 0.5 | 1 | |
M45A | patA | 1 | 1 | 1 | 0.5 | 0.5 | 0.5 | |
M45B | patB | 1 | 1 | 1 | 0.5 | 0.5 | 0.5 | |
M50 | FQDR | 64 | 32 | 32 | 4 | 0.5 | 1 | |
M50A | patA | 4 | 4 | 4 | 0.5 | 0.5 | 0.5 | |
M50B | patB | 4 | 4 | 4 | 0.5 | 0.5 | 0.5 | |
M74 | FQDR | 64 | 32 | 64 | 4 | 0.5 | 1 | |
M301 | patA | 8 | 8 | 8 | 0.5 | 0.5 | 0.25 | |
M305 | patB | 8 | 8 | 8 | 0.5 | 0.5 | 0.25 | |
M86 | FQDR | 2 | 0.5 | 0.5 | 4 | 0.5 | 0.5 | |
M86A | patA | 1 | 0.5 | 0.5 | 0.5 | 0.5 | 0.5 | |
M86B | patB | 1 | 0.5 | 0.5 | 0.5 | 0.5 | 0.5 | |
M87 | FQDR | 32 | 8 | 16 | 4 | 0.5 | 1 | |
M87A | patA | 8 | 8 | 8 | 0.5 | 0.5 | 0.5 | |
M87B | patB | 8 | 8 | 8 | 0.5 | 0.5 | 0.5 | |
M296 | FQDR | 2 | 0.5 | 8 | 8 | 0.5 | 2 | |
M304 | patA | 4 | 1 | 2 | 0.5 | 0.5 | 0.25 | |
M310 | patB | 4 | 1 | 2 | 16 | 0.5 | 8 | |
M297 | FQDR | 8 | 2 | 8 | 8 | 0.5 | 1 | |
M311 | patA | 8 | 4 | 4 | 0.5 | 0.5 | 8 | |
M311B | patB | 8 | 4 | 4 | 0.5 | 0.5 | 8 | |
M79 | FQ-R | 32 | 32 | 16 | 2 | 0.5 | 0.5 | |
M316 | patA | 8 | 8 | 8 | 0.25 | 0.5 | 0.5 | |
M317 | patB | 8 | 8 | 8 | 0.5 | 0.5 | 0.5 | |
M83 | FQ-R | 64 | 64 | 1 | 8 | 4 | 4 | |
M318 | patA | 16 | 16 | 16 | 0.5 | 0.5 | 0.5 | |
M319 | patB | 16 | 16 | 16 | 0.5 | 0.5 | 0.5 | |
M97 | FQ-R | 8 | 4 | 8 | 4 | 0.5 | 1 | |
M302 | patA | 4 | 4 | 4 | 0.5 | 0.5 | 0.5 | |
M306 | patB | 4 | 4 | 4 | 0.25 | 0.5 | 0.5 | |
M98 | FQ-R | 32 | 2 | 32 | 4 | 0.12 | 1 | |
M314 | patA | 8 | 8 | 8 | 0.5 | 0.5 | 0.5 | |
M307 | patB | 8 | 8 | 8 | 2 | 0.5 | 2 | |
M100 | FQ-R | 8 | 2 | 1 | 4 | 0.25 | 1 | |
M315 | patA | 2 | 1 | 0.12 | 0.25 | 0.12 | 0.25 | |
M308 | patB | 2 | 1 | 0.12 | 0.25 | 0.25 | 0.5 | |
M55 | DR | 0.25 | 0.5 | 0.5 | 16 | 0.5 | 1 | |
M300 | patA | 2 | 2 | 2 | 0.5 | 0.5 | 0.5 | |
M55B | patB | 2 | 2 | 2 | 0.5 | 0.5 | 0.5 | |
M46 | DR | 0.25 | 0.5 | 0.5 | 16 | 0.5 | 1 | |
M46A | patA | 0.12 | 0.12 | 0.12 | 0.5 | 0.5 | 0.5 | |
M46B | patB | 0.12 | 0.12 | 0.12 | 0.5 | 0.5 | 0.5 | |
M295 | S | 1 | 0.5 | 0.25 | 2 | 0.25 | 0.5 | |
M303 | patA | 2 | 1 | 0.12 | 1 | 0.5 | 1 | |
M309 | patB | 4 | 1 | 2 | 16 | 0.5 | 8 |
Abbreviations are as defined for Table 3. MICs of each agent for the parent strains in which patA and patB are active are highlighted in boldface.