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. 2010 Oct 18;55(1):338–348. doi: 10.1128/AAC.01052-10

FIG. 6.

FIG. 6.

Tulathromycin-induced apoptosis is cell (A) and drug (B) selective. (A) Administration of tulathromycin increases levels of apoptotic mono-/oligonucleosomes in bovine neutrophils (PMN) but not in bovine epithelial cells (MDBK), fibroblasts (EBTr), endothelial cells (CPA47), freshly isolated blood monocytes (MONO), or monocyte-derived macrophages (MAC). (B) Tulathromycin (TUL; 2 mg/ml) but not ceftiofur (CEFT), oxytetracycline (OXYTET), or penicillin G (PEN-G) added at equimolar concentrations for 0.5 h increases levels of apoptosis in bovine neutrophils. Values were calculated as absorbance ratios versus values measured in neutrophils from control samples incubated with HBSS, arbitrarily set to 1.0. Values are means ± standard errors of the means. n = 4/group. *, P < 0.05 versus control.