FIG. 1.

Population pharmacokinetic model for the simultaneous prediction of nevirapine concentrations in the mother, the cord (fetus; top), and the neonate (bottom). A one-compartment model with first-order absorption and elimination best described maternal data. For cord concentrations, an effect compartment is modeled as a virtual compartment linked to the maternal plasma compartment by a first-order process. After delivery, the fetal compartment is disconnected and the neonate has his or her own absorption and elimination.