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Cellular morphology. Distinct changes in morphology (40×) were observed as caspofungin was added to a final concentration of 0.12 μg/ml. (A and B) The susceptible strain KU80 ΔakuB showed fully formed hyphae with no drug (A) but was unable to develop fully when drug was present (B). (C and D) The resistant strain with a mutation in FKS1 did not show any changes in morphology in the absence (C) or presence (D) of drug.
