TABLE 1.
Compounds synthesized
| Starting amine (n)a | No. of amines derivatizedb |
||
|---|---|---|---|
| Guanide | Biguanide | Phenylguanide | |
| Butanediamine (2) | 2 | 2 | 1 or 2 |
| Hexanediamine (2) | 2* | 1 or 2 | 1 or 2 |
| Diethylenetriamine (3) (DETA) | 2 | 3† | 3‡ |
| Spermidine (3) | 2 or 2-3 | 1-2 | 2 or 3 |
| Spermine (4) | 2 | 2 | 3-4 |
| Trisethylaminomelamine (3) (TEAM) | 3 | 1 | 3 |
| Trisbutylaminomelamine (3) (TBAM) | 3 | 1-2 | 2 or 3 |
| Trishexylaminomelamine (3) (THAM) | 3 | 1-3 | 2 |
| Bisethylaminomelamine dimer (2) (BEMA dimer) | 2 | ND | 1-2 |
| PAMAM G0 (4) | 4* | 3-4 | 4** |
| DNT2300 (6) | 5-6* | 3-6¶ | 6 |
| DNT2200 (8) | 8 | 1-5 | 8 |
a
n, number of reactive amines in each starting material.
b
*, +15 mass also (O-Me replace NH2); **, small amount of +5 phenylguanide groups; †, cyanoamines and biguanides; ‡, cyclic by-products; ¶, masses 4 amu too low. ND, synthesis not done.