Surface representation of the cleft showing amino acids within 4 Å of the putative catalytic serine (Ser 368) of the PBP1 transpeptidase region from 26695. In addition, although Arg 543 from the superimposed structure B258 is located about 19 Å away from the putative catalytic Ser 368, it potentially interferes with ligand entry. Blue, nitrogen; red, oxygen; white, carbon.