FIG. 6.

(a) The localization and stick structure representation of 4 key amino acids within the putative binding cleft in strain 26695 (amoxicillin susceptible). (b) The predicted stick structure representation of unique amino acid substitutions for these 4 amino acids which have been previously reported to increase amoxicillin resistance in various clinical strains. Amino acid side chains depicted in stick representations are colored by type (green, hydrophobic; yellow, polar; blue, positively charged).