TABLE 1.
Detection of GPCMV in dam and fetal organs by real-time PCR at 10 days postinoculationa
| Group and treatment regimenb | Liver |
Spleen |
Placenta |
|||
|---|---|---|---|---|---|---|
| No. positive/total no. (%) | Viral load (P value) | No. positive/total no. (%) | Viral load (P value) | No. positive/total no. (%) | Viral load (P value) | |
| Dam | ||||||
| Control | 4/4 (100) | 4.82 ± 0.8 | 4/4 (100) | 4.12 ± 0.3 | 15/15 (100) | 3.40 ± 0.7 |
| HDP-CDV 4 mg/kg × 5d | 4/4 (100) | 2.98 ± 1.3 (0.050) | 4/4 (100) | 2.77 ± 1.2 (0.067) | 13/13 (100) | 2.70 ± 0.9 (0.041) |
| HDP-CDV 4 mg/kg × 9d | 5/5 (100) | 3.01 ± 1.0 (0.024) | 5/5 (100) | 2.09 ± 0.5 (<0.001) | 13/13 (100) | 2.75 ± 0.5 (0.009) |
| Fetus | ||||||
| Control | 13/15 (87) | 2.20 ± 0.6 | 7/15 (47) | 1.63 ± 0.6 | ||
| HDP-CDV 4 mg/kg × 5d | 12/13 (92) | 2.12 ± 0.7 (0.265) | 10/13 (77) | 1.91 ± 0.6 (0.218) | ||
| HDP-CDV 4 mg/kg × 9d | 11/13 (85) | 1.87 ± 0.6 (0.752) | 8/13 (62) | 1.65 ± 0.5 (0.563) | ||
a
Viral load values represent the mean log10 genome copies/μg DNA ± standard deviations. All P values compare treated and control groups. Significant P values are shown in bold. Data shown are from one study each.
b
HDP-CDV 4 mg/kg × 5d, treatment with 4 mg/kg HDP-CDV for 5 days; HDP-CDV 4 mg/kg × 9d, treatment with 4 mg/kg HDP-CDV for 9 days.