Table 1.

α-Gal A enzyme activities in organs derived from mice killed at 2, 5, 15, and 25 weeks after rAAV-AGA treatment

Group (no. of mice)	Enzyme activity (nmole/hr per mg protein)
	Liver	Spleen	Heart	Lung	Kidney	Small intestine
Wild-type mice (8)	72.5  ± 6.20	236.2  ± 26.90	7.2  ± 1.10	71.3  ± 14.80	32.5  ± 9.00	195  ± 40.40
Untreated Fabry mice (8)	1.4  ± 0.12	3.8  ± 0.94	0.3  ± 0.12	1.8  ± 0.26	1.2  ± 0.47	3.3  ± 1.55
Treated mice (4) 2 weeks postinjection	20.9  ± 4.53†	6.3  ± 4.36	1.4  ± 0.18†	3.9  ± 0.95	4.0  ± 4.65	22.3  ± 3.06†
Treated mice (4) 5 weeks postinjection	8.2  ± 1.14†	26.3  ± 0.03†	1.5  ± 0.21†	6.6  ± 0.40†	6.2  ± 0.08*	11.4  ± 3.25*
Treated mice (4) 15 weeks postinjection	3.8  ± 0.68†	18.0  ± 0.01†	0.6  ± 0.25	5.6  ± 1.63*	2.0  ± 0.01*	8.2  ± 2.20*
Treated mice (3) 25 weeks postinjection	6.0  ± 0.79†	30.3  ± 0.03*	1.3  ± 0.61	6.7  ± 1.02*	4.0  ± 0.03*	13.0  ± 5.00

^*, P < 0.05 vs. untreated Fabry mice (unpaired t test);  

^†, P < 0.01.