Table 2.

Gb3 levels in tissues from mice rAAV-AGA-injected mice killed at 2, 5, 15, and 25 weeks posttreatment

Tissue	Animals	Gb3 levels, nmole/mg protein
		2 weeks	5 weeks	15 weeks	25 weeks
Liver	Untreated Fabry mice	2.02  ± 0.31	7.37  ± 2.34	8.58  ± 0.75	9.31  ± 4.64
	Wild-type mice	0.04  ± 0.01	0.05  ± 0.01	0.12  ± 0.01	0.05  ± 0.01
	Treated Fabry mice	0.15  ± 0.09*	0.23  ± 0.06*	3.85  ± 1.97*	2.22  ± 1.33†
Spleen	Untreated Fabry mice	N/D	26.37  ± 5.47	29.57  ± 2.11	20.65  ± 4.39
	Wild-type mice	N/D	0.31  ± 0.06	0.59  ± 0.01	0.2  ± 0.13
	Treated Fabry mice	N/D	5.04  ± 2.03*	22.71  ± 5.13	12.82  ± 6.39†
Heart	Untreated Fabry mice	N/D	2.02  ± 1.30	3.18  ± 0.23	3.1  ± 0.44
	Wild-type mice	N/D	0.22  ± 0.20	0.07  ± 0.00	0.03  ± 0.01
	Treated Fabry mice	N/D	0.69  ± 0.25†	1.50  ± 0.50*	1.70  ± 0.97†
Kidney	Untreated Fabry mice	13.26  ± 0.95	13.69  ± 1.00	16.1  ± 1.16	12.48  ± 2.96
	Wild-type mice	1.39  ± 0.10	1.60  ± 0.11	1.37  ± 0.28	0.96  ± 0.81
	Treated Fabry mice	9.83  ± 1.12†	12.65  ± 3.57	13.85  ± 2.94	16.56  ± 9.12
Lung	Untreated Fabry mice	3.57  ± 0.48	6.04  ± 1.99	7.22  ± 2.31	7.46  ± 1.70
	Wild-type mice	0.27  ± 0.06	0.23  ± 0.04	0.38  ± 0.13	0.56  ± 0.07
	Treated Fabry mice	2.04  ± 0.19*	1.38  ± 0.68*	5.61  ± 1.36	6.45  ± 3.21

Gb3 levels are expressed as average ± SD. N/D, not determined. 

 *, P < 0.01;  

^†, P < 0.05 vs. untreated Fabry mice.