TABLE 1.
Deletion of PI3KC2α alters serum chemistry and hematology values consistent with renal disease
| Measured parameter | Resulta for: |
|
|---|---|---|
| PI3KC2α+/+ mice (n = 8) | PI3KC2α−/− mice (n = 14) | |
| Blood chemistry | ||
| Alanine transferase (U/liter) | 40.8 ± 7.3 | 29.7 ± 6.7 |
| Alkaline phosphatase (U/liter) | 138.6 ± 15.2 | 256.1 ± 28.4** |
| Bilirubin (mg/dl) | 0.3 ± 0.0 | 0.2 ± 0.0* |
| BUN (mg/dl) | 28.0 ± 1.7 | 74.5 ± 14.2* |
| Calcium (mg/dl) | 9.9 ± 0.2 | 11.0 ± 0.2** |
| Chloride (mM) | 110.2 ± 0.5 | 110.9 ± 0.8 |
| Cholesterol (mg/dl) | 166.0 ± 32.1 | 254.1 ± 22.4* |
| Creatinine (mg/dl) | 0.1 ± 0.0 | 0.2 ± 0.0** |
| Globulin (mg/dl) | 1.9 ± 0.1 | 2.3 ± 0.1* |
| Glucose (mg/dl) | 147.0 ± 6.6 | 136.3 ± 6.9 |
| Potassium (mM) | 4.2 ± 0.1 | 4.6 ± 0.1** |
| Sodium (mM) | 146.5 ± 0.4 | 146.5 ± 0.4 |
| Phosphate (mg/dl) | 6.7 ± 0.3 | 8.0 ± 0.2** |
| Total protein (g/dl) | 5.3 ± 0.1 | 5.1 ± 0.1 |
| Triglycerides (mg/dl) | 56.5 ± 8.4 | 75.1 ± 11.9 |
| Uric acid (mg/dl) | 1.2 ± 0.2 | 0.9 ± 0.0 |
| Hematology | ||
| Hb (g/dl) | 15.3 ± 0.2 | 12.6 ± 1.1** |
| Hematocrit (%) | 55.1 ± 1.0 | 46.5 ± 3.9** |
| Mean platelet vol (fl) | 4.2 ± 0.0 | 4.5 ± 0.1** |
| Platelets (×10−6/ml) | 539.1 ± 15.1 | 748.0 ± 124.0* |
| RBCs (×10−9/ml) | 10.1 ± 0.1 | 8.4 ± 0.7* |
a
Values for mice at 6 weeks of age. *, P ≤ 4 × 10−2; **, P ≤ 4 × 10−3.