TABLE 3.

Cellular role category enrichment based on JCVI CRCs

CRC	Total no. of proteins on the array	Immunization with live EB			Immunization with UV-EB
		No. of hits	Fold enrichmenta	P value	No. of hits	Fold enrichmenta	P value
Amino acid biosynthesis	14	1	0.34	0.32	1	0.85	1.0
Biosynthesis of cofactors	31	4	0.62	0.37	1	0.38	0.51
Cell envelope	45	11	1.17	0.57	3	0.79	1.0
Cellular processes	45	17	1.80b	0.0078	8	2.12b	0.046
Central intermediary metabolism	12	2	0.79	1.0	1	0.99	1.0
DNA metabolism	52	5	0.46	0.36	2	0.46	0.31
Energy metabolism	61	8	0.63	0.14	5	0.98	1.0
Fatty acid and phospholipid metabolism	23	5	1.04	1.0	3	1.56	0.43
Hypothetical protein	75	15	0.95	1.0	5	0.79	0.83
Hypothetical protein: conserved	275	60	1.04	0.72	22	0.95	0.90
Protein fate	58	27	2.22b	6.4 × 10−6	15	3.08b	3.1 × 10−5
Protein synthesis	97	13	0.64	0.064	3	0.37	0.051
Purines, pyrimidines	15	4	1.27	0.53	1	0.79	1.0
Regulatory functions	16	1	0.30	0.22	0	0.00	0.39
Transcription	23	9	1.87b	0.039	4	2.07	0.12
Transport and binding	55	7	0.61	0.17	3	0.65	0.62
Unknown function	33	6	0.87	0.83	1	0.36	0.52
Total	930	195			78

^aRelative to the percentage represented in the genome.

^bP value of <0.05.