FIG. 5.

Primary structures of deduced products of vestigial myeloid α-defensin-like pseudogenes in the mouse genome. The deduced products of mouse vestigial myeloid α-defensin pseudogenes identified in the NIH (A) and Celera (B) mouse genome assemblies are aligned. The corresponding provisional gene symbols (Fig. 4A and B and Tables 1 and 2) used (DefmaN-ps^N or -ps^C) are based on gene positions, with the most telomeric gene assigned as Defma1-ps^N/C. DefmaN-ps^N/C sequences are shown aligned with RatNP-1/2 (i.e., the Defa1/2 gene product) as a reference. Deduced gene products with extensive similarity to Defcr-coded prepro regions were designated DefmaN-ps^HybN/C to denote that they are chimeras of mouse Crp and other α-defensin pseudogene sequences. The products of DefmaN-ps gene second exons and the first exons of DefmaN-ps^Hyb genes are deduced prepro regions. The deduced products of DefmaN-ps gene third exons and the second exons of DefmaN-ps^Hyb genes are α-defensins. Asterisks denote stop codons, hyphens denote gap positions, angle brackets denote mutated splice junctions, and the slashes denote frameshifted sequences.