TABLE 3.
Relative risk of mortality for pairwise comparisons of wt versus mutant P. gingivalis infections in Drosophila
|
P. gingivalis strains |
RR (P value) for wt vs mutanta | Findings in other animal model studies (reference[s]) for: |
||
|---|---|---|---|---|
| Mutant | wt | Periodontal bone loss | Abscess and death | |
| rgpA rgpB mutant (arginine-specific proteases) | W50UK | 7.69 (<0.0001) | −b | Correlation (15) |
| kgp mutant (lysine-specific protease) | W83VA | 1.63 (<0.0001) | − | Correlation (15) |
| fimA mutant (fimbrillin, major fimbriae) | 33277FL | 2.13 (<0.0001) | Correlation (14, 46) | − |
| mfa1 mutant (minor fimbriae) | 33277FL | 1.56 (0.0018) | Correlation (46) | − |
| Capsule mutant | W50UK | 2.99 (<0.0001) | − | − |
| mgl mutant | W83JP | 0.87 (0.2) | − | No correlation (47) |
a
RR values with P values of <0.05 are shown in bold.
b
−, the strains have not been compared in the indicated model.