FIG. 9.
Guinea pig challenges with wild-type (WT) Ames or complemented mutant strains. Guinea pigs were challenged intramuscularly with approximately 1 × 103 Ames, ΔpurH (P, 0.017 for the percentage of guinea pigs surviving and 0.0240 for the survival curve compared with the WT), ΔpurH + purH (P, 1 for the percentage of guinea pigs surviving, 0.024 for the survival curve, and <0.0001 for TTD compared with the WT), ΔpurH + purD (P, 1 for the percentage of guinea pigs surviving and 0.3 for the survival curve compared with those for the ΔpurH mutant), or ΔpurD + purD (P, ≥0.05 for all tests conducted compared with the WT) spores.