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Time course of selection of genes during the GAF rabbit meningitis screen. Shown are the numbers of mutants with mutations of S. pneumoniae genes that had become attenuated (A) or enriched (B) at 3, 9, or 15 h postinfection. The shading indicates the first time at which genes were selected: 3 (open bars), 9 (shaded bars), or 15 (filled bars) h postinfection. Hrs, time postinfection.
