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. 2010 Oct 11;79(1):499–511. doi: 10.1128/IAI.00888-10

TABLE 6.

Geometric means and 95% confidence intervals for the expression of each gene by clinical categorya

Gene C (n = 386)
 TT (n = 142)
 TTI (n = 244)
 TTI vs C
 TT vs C
 TTI vs TT
 Pd
Mean 95% CI Mean 95% CI Mean 95% CI FC Pb FC Pb FC Pc
IFNγ 0.0212 0.0191-0.0235 0.0194 0.0167-0.0225 0.0178 0.0157-0.0203 0.78 0.0433 1.03 0.8282 0.92 0.4293 0.1105
TNFα 0.2064 0.1964-0.2169 0.2261 0.2013-0.2539 0.2370 0.2150-0.2613 1.11 0.0767 1.16 0.0403 1.05 0.5474 0.0236
IL1B 0.6248 0.5763-0.6775 1.1038 0.9131-1.3343 1.4000 1.2127-1.6164 2.18 <0.0001 1.86 <0.0001 1.27 0.0489 <0.0001
IL10 0.0361 0.0321-0.0407 0.0429 0.0346-0.0532 0.0418 0.0358-0.0487 1.08 0.4941 1.34 0.0660 0.97 0.8449 0.2055
IL13 0.0018 0.0016-0.0022 0.0012 0.0007-0.0015 0.0009 0.0007-0.0011 0.45 0.0002 0.72 0.0545 0.75 0.3895 <0.0001
IL13RA2 0.0083 0.0075-0.0093 0.0184 0.0153-0.0223 0.0178 0.0149-0.0214 2.17 <0.0001 2.12 <0.0001 0.97 0.7785 <0.0001
IL19e 0.00003 0.00002-0.00004 0.0001 0.00007-0.00014 0.0001 0.00009-0.00016 2.98 0.0001 3.10 0.0227 1.29 0.2400 <0.0001
ARG1 0.0331 0.0310-0.0353 0.0408 0.0349-0.0476 0.0432 0.0383-0.0489 1.30 0.0007 1.24 0.0109 1.06 0.5599 0.0001
NOS2A 0.7908 0.7247-0.8629 2.0494 1.7665-2.3776 2.4573 2.1770-2.7737 3.28 <0.0001 2.36 <0.0001 1.20 0.0671 <0.0001
INDO 1.0955 0.9907-1.2113 3.4223 2.9046-4.0323 4.3953 3.8411-5.0295 4.10 <0.0001 3.02 <0.0001 1.28 0.0232 <0.0001
CXCL5 0.0070 0.0058-0.0084 0.0248 0.0178-0.0344 0.0419 0.0323-0.0543 6.39 <0.0001 3.15 <0.0001 1.69 0.0145 <0.0001
S100A7 0.3972 0.3568-0.4421 3.4075 2.4726-4.6959 5.8468 4.5231-7.5579 14.61 <0.0001 8.69 <0.0001 1.72 0.0109 <0.0001
MMP7 1.0005 0.9169-1.0917 2.7078 2.2781-3.2186 3.1925 2.8415-3.5868 3.14 <0.0001 2.79 <0.0001 1.18 0.1079 <0.0001
MMP9 0.0340 0.0305-0.0378 0.0570 0.0478-0.0679 0.0633 0.0554-0.0723 1.88 <0.0001 1.65 0.0001 1.11 0.3429 <0.0001
MMP12 0.4047 0.3662-0.4473 0.7397 0.6247-0.8759 0.8437 0.7329-0.9714 2.08 <0.0001 1.84 <0.0001 1.14 0.2501 <0.0001
HAS3 0.1456 0.1313-0.1613 0.2232 0.1904-0.2619 0.2441 0.2133-0.2793 1.68 <0.0001 1.53 0.0001 1.09 0.4136 <0.0001
IL13/IL13RA2f 0.1911 0.1556-0.2348 0.0505 0.0340-0.0750 0.0425 0.0330-0.0547 0.20 <0.0001 0.28 0.0001 0.84 0.4435 <0.0001
a

The expression levels are standardized relative to the expression of HPRT1 in the same reaction. FC, fold change (a value of >1 indicates increased expression in the first clinical category of each comparison compared to the second).

b

P values for paired t test. Using the Bonferroni correction, the critical significance threshold level is a P value of <0.001.

c

P values for unpaired t test. Using the Bonferroni correction, the critical significance threshold level is a P value of <0.001.

d

As determined by analysis of variance of the expression level of the gene across the three clinical categories.

e

For IL19, only cases or controls where expression was detected are included.

f

That is, the ratio of IL13/IL13RA expression.