TABLE 1.

Data indicating progression of infection and kidney pathological changes in mice infected i.v. with five C. albicans strains^a

Time (h)	Strain	Lesion area (mm2)	No. of infiltrate pixels (mm−2)b	Log CFU g of kidney−1	Weight change (%) (day 3 to day 0)	Outcome score
12	NGY152			4.4 ± 0.4
	pmr1Δ mutant			4.9 ± 0.2
	pmr1Δ/PMR1 mutant			4.5 ± 0.2
	mnt1/2Δ mutant			4.5 ± 0.2
	mnt1/2Δ/MNT1mutant			4.3 ± 0.2
24	NGY152	2.0 ± 0.4	36 ± 17	5.4 ± 0.2
	pmr1Δ mutant	2.1 ± 0.8	35 ± 31	5.3 ± 0.3
	pmr1Δ/PMR1 mutant	1.9 ± 1.0	31 ± 18	5.0 ± 0.3
	mnt1/2Δ mutant	1.8 ± 0.8	43 ± 16	5.4 ± 0.4
	mnt1/2Δ/MNT1mutant	1.8 ± 0.5	32 ± 11	5.2 ± 0.2
48	NGY152	2.4 ± 0.7	80 ± 26	5.9 ± 0.5
	pmr1Δ mutant	3.2 ± 0.4	120 ± 100	5.9 ± 0.5
	pmr1Δ/PMR1mutant	2.5 ± 0.7	95 ± 35	6.0 ± 0.3
	mnt1/2Δ mutant	2.6 ± 1.8	110 ± 71	5.9 ± 0.5
	mnt1/2Δ/MNT1mutant	3.6 ± 1.7	140 ± 53	6.1 ± 0.5
72	NGY152			6.5 ± 0.5	−15 ± 4.5	14 ± 2.7
	pmr1Δ mutant			6.5 ± 0.8	−15 ± 6.7	14 ± 3.9
	pmr1Δ/PMR1mutant			6.3 ± 0.5	−15 ± 4.2	14 ± 2.5
	mnt1/2Δ mutant			6.4 ± 0.4	−15 ± 2.3	14 ± 1.2
	mnt1/2Δ/MNT1mutant			6.1 ± 0.5	−18 ± 1.8	16 ± 1.0

^aAll data expressed to 2 significant figures and shown as means ± standard deviations. Microscopy data (lesion area and number of infiltrate pixels mm⁻²) were determined with groups of six mice sampled at random from among the mice tested. Fungal burdens in kidneys, 3-day weight changes, and outcome scores were determined for the same groups of 9 mice that were used for chemokine and cytokine assays.

^bThe number of pixels is shown in thousands (e.g., 36 ± 17 in the table means 36,000 ± 17,000).