FIG. 6.

Model of NadA-NadA receptor interaction. The picture shows the predicted globular head (aa 24 to 42, subdomain I; aa 43-87, subdomains II and III) and the neighboring intrachain coiled-coil domain (aa 88-133, ccD). It is proposed that the regions around sequences of aa 24 to 39 and 94 to 121 form the surface interacting with the NadA receptor (R), while aa 42 to 88 are not directly associated with NadA receptor. The possible interaction with specific Fab fragments and NadA receptor is also depicted to account for competition studies. A single polypeptide chain of the three forming the adhesin oligomer is shown here for clarity.