TABLE 2.

Effect of the taurocholate side chain (R) on C. difficile spore germination

a C. difficile spores were individually treated with 6 mM glycine and 12 mM taurocholate analogs T11 to T22. The percent germination was calculated based on taurocholate/glycine germination set as 100%. Standard deviations are shown in parentheses.

b C. difficile spores were incubated with various concentrations of taurocholate analogs for 15 min prior to the addition of 6 mM taurocholate and 12 mM glycine. The IC₅₀ was calculated by plotting the extent of germination versus the logarithm of analog T11 to T22 concentrations. Standard deviations are shown in parentheses.

c N/A, no activity under the conditions tested.