TABLE 2.
Conservation of type II CGβ genes in African great apes
| Species | Gene | S/NSa | Indeld | Comment |
|---|---|---|---|---|
| Human | CGβ1 | 4/3 | Premature stop: 8-aa C-terminal truncation | |
| CGβ2 | 1/0 | |||
| Chimpanzee | CGβ1 | 0/5b | ||
| CGβ1B | 2/1 | |||
| Gorilla | CGβ1 | 1/3c | 1 In | Single nucleotide insertion: frameshift |
| CGβ2 | 2/3b | 12 Del | Deletion of 12 nucleotides: loss of 4 Leu residues |
a
Synonymous (S) and nonsynonymous (NS) nucleotide changes in the CGβ reading frame (frame 2) of CGβ1 and CGβ2 genes, as determined by their departure from the consensus in the type II sequence alignment (see data set S6 in the supplemental material).
b
All nonsynonymous changes result in neutral or nonconservative amino acid changes based on the Blosum 62-amino-acid substitution matrix (25), except for a Lys-to-Arg change in gorilla CGβ2.
c
Many nonconservative amino acid changes due to frameshift after residue 31.
d
Nucleotide insertions (In) and deletions (Del).