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The cyclin A-C1 mutant can promote phosphorylation and inactivation of the retinoblastoma protein (Rb). Rb-deficient SaOS-2 cells were cotransfected with 1 μg of GFP-expressing vector and 5 μg of mock or Rb-expressing vector with or without 5 μg of wild-type (WT) and mutant (C1) cyclin A-expressing vectors and subjected to FACS analysis of the GFP-positive cells (a) and anti-Rb Western blot analysis (b). Rb-p, the phosphorylated form of Rb.
