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. 2010 Nov 10;85(2):865–872. doi: 10.1128/JVI.01412-10

FIG. 4.

FIG. 4.

Analysis of the receptor-binding pocket of HA63-286-RBD. (A) Overlay of the receptor-binding pockets of HA63-286-RBD (green) and the A/H1N1/2009 HA ectodomain (blue). The coordinates for the A/H1N1/2009 HA ectodomain are from PDB entry 3LZG. (B) Structural model of a sialic acid molecule within the receptor-binding pocket of HA63-286-RBD. The model is based on the structure of the 1934 H1 HA ectodomain bound to a human sialic acid receptor analog (PDB entry 1RVZ). (C) Observed binding of a glycerol molecule in the receptor-binding pocket of HA63-286-RBD. Glycerol occupies the site that recognizes the 8-OH and 9-OH moiety of sialic acid. All residues are labeled using H3 numbering.