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. 2010 Nov 26;30(1):5–16. doi: 10.1038/emboj.2010.299

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Copyright © 2011, European Molecular Biology Organization

This is an open-access article distributed under the terms of the Creative Commons Attribution Noncommercial No Derivative Works 3.0 Unported License, which permits distribution and reproduction in any medium, provided the original author and source are credited. This license does not permit commercial exploitation or the creation of derivative works without specific permission.

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The Pex11-Amph peptide tubulates SUVs of lipid composition similar to peroxisomal membranes. Electron micrographs of SUVs following incubation with the Pex11-Amph peptide. The PC, PC/PE and PC/PE/PS/PI/CL liposomes do not form any elongated structures in the absence of Pex11-Amph (A–C). Also, addition of the Pex11-Amph peptide to SUVs consisting of PC (D) or PC/PE (E) did not alter the shape of these vesicles. Addition of the Pex11-Amph peptide resulted in extensive tubulation of vesicles that had a phospholipid content resembling that of the peroxisomal membrane (F). Mutant peptides Pex11-Amph-Φ (G–I) and Pex11-Amph-P (J–L) were unable to tubulate both neutral and negatively charged vesicles. The bars represent 500 nm.