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. 2010 Sep 9;89(2):446–456. doi: 10.1093/cvr/cvq291

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Published on behalf of the European Society of Cardiology. All rights reserved. © The Author 2010. For permissions please email: journals.permissions@oxfordjournals.org.

The online version of this article has been published under an open access model. Users are entitled to use, reproduce, disseminate, or display the open access version of this article for non-commercial purposes provided that the original authorship is properly and fully attributed; the Journal, Learned Society and Oxford University Press are attributed as the original place of publication with correct citation details given; if an article is subsequently reproduced or disseminated not in its entirety but only in part or as a derivative work this must be clearly indicated. For commercial re-use, please contact journals.permissions@oxfordjournals.org.

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TGF-β receptor activity. (A) Estimation of TGFβR1/2 activity by measurement of TGFβR1 phosphorylation. Results are expressed as the ratio of pTGFβR1/TGFβR1. *Significant decrease in TGFβR1 phosphorylation in aneurysmal media from patients with TGFBR2 mutations (Q508Q and R357C) compared with controls and other types of TAA (P < 0.05). (B) Dissociation between Smad2 activation and TGF-β receptor activity in aneurysmal SMCs. *P < 0.01, treated vs. non-treated conditions. ^#P < 0.05 vs. control.