Table 1. Demographic, clinical, genotype characteristics of validation cohort.
| Characteristic | CDR 0 | CDR 0.5 | CDR 1 |
| Number of Participants | 198 | 65 | 29 |
| Gender (% Female) | 63% | 54% | 52% |
| APOE genotype, % ε4 positive | 35% | 51% | 59% |
| Mean MMSE score (SD) | 28.9 (1.3) | 26.3 (2.8) | 22.3 (3.9) |
| Mean age at LP (SD), years | 71.0 (7.3) | 73.8 (6.8) | 76.5 (6.2) |
| Mean CSF Aβ42 (SD), pg/mL | 605 (240) | 446 (230) | 351 (118) |
| Mean CSF tau (SD), pg/mL | 304 (161) | 539 (276) | 552 (263) |
| Mean CSF p-tau181 (SD), pg/mL | 55 (25) | 85 (44) | 77 (38) |
Abbreviations: CDR, Clinical Dementia Rating; CDR 0, cognitively normal; CDR 0.5, very mild dementia; CDR 1 mild dementia; APOE, apolipoprotein E; MMSE, Mini-Mental State Examination; LP, lumbar puncture; SD, standard deviation; CSF, cerebrospinal fluid; Aβ42, amyloid beta 42 peptide; p-tau181, tau phosphorylated at threonine 181.